Estimating De Novo Mutational Signatures for Germline Variants

[lincj1994]

Hi,

I’m wondering if this tool can be used to estimate de novo mutational signatures for germline variants. Is there a difference in how mutational signatures are estimated for germline versus somatic variants?

Thanks in advance for your help!

[ShixiangWang]

Yeah, you can use any similar tools for your job. However, as the COSMIC signatures were derived somatic mutations, you need to take care of your explanation for your data.