Using BIOS F12k and upgrading Opencore to 0.7.5, you can now enable Resizable BAR in the bios (for gaming speedup in Windows) without breaking macOS boot.
See here: https://www.reddit.com/r/hackintosh/comments/q6ik75/booting_macos_with_resizeable_bar_enabled_is_now/
Just requires 2 quirks enabled as shown in link above ^
Confirmed working on my system (I was able to set AppleGpuBars to 8 without issue) and should be good to enable by default for any system running F12K. I did not test any other BIOS version, but I would imagine it will work just fine.