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Could you please tell me which version of libgtk2.0 you are using under Linux? I use Ubuntu 16.04 and it was working before, but on another system which I thought was the same setup, I get an error that it fails to initalialize Pango.Layout because Glib.GType.GetClassSize() is not found. I use, as you said, gtk-sharp 2.12 and everything compiles fine. It starts and runs, but when something triggers that Pango.Layout init issue. The stacktrace tells nothing of what is actually happening.
Would you have any clue or can you tell me what versions you are using yourself under Linux?