diff --git a/pandas/core/frame.py b/pandas/core/frame.py
index 48a5596e00061..ccae46f1e3dde 100644
--- a/pandas/core/frame.py
+++ b/pandas/core/frame.py
@@ -3995,6 +3995,17 @@ def __getitem__(self, key):
         key = lib.item_from_zerodim(key)
         key = com.apply_if_callable(key, self)
 
+        if (
+            isinstance(key, (list, np.ndarray))
+            and len(key) > 0
+            and any(isinstance(k, bool) for k in key)
+            and all(isinstance(k, (bool, str)) for k in key)
+            and not (
+                len(key) == len(self.index) and all(isinstance(k, bool) for k in key)
+            )
+        ):
+            return self.reindex_columns(key)
+
         if is_hashable(key) and not is_iterator(key) and not isinstance(key, slice):
             # is_iterator to exclude generator e.g. test_getitem_listlike
             # As of Python 3.12, slice is hashable which breaks MultiIndex (GH#57500)
diff --git a/pandas/tests/frame/indexing/test_getitem.py b/pandas/tests/frame/indexing/test_getitem.py
index 25d6e06a4c675..5d1744725f114 100644
--- a/pandas/tests/frame/indexing/test_getitem.py
+++ b/pandas/tests/frame/indexing/test_getitem.py
@@ -101,6 +101,13 @@ def test_getitem_list_duplicates(self):
         expected = df.iloc[:, 2:]
         tm.assert_frame_equal(result, expected)
 
+    def test_getitem_single_bool_column(self):
+        #  GH#61980
+        df = DataFrame({True: [10, 20, 30]})
+        result = df[[True]]
+        expected = DataFrame({True: [10, 20, 30]})
+        tm.assert_frame_equal(result, expected)
+
     def test_getitem_dupe_cols(self):
         df = DataFrame([[1, 2, 3], [4, 5, 6]], columns=["a", "a", "b"])
         msg = "\"None of [Index(['baf'], dtype="