diff --git a/Include/internal/pycore_interp_structs.h b/Include/internal/pycore_interp_structs.h
index f1f427d99dea69..a3357d65e7b754 100644
--- a/Include/internal/pycore_interp_structs.h
+++ b/Include/internal/pycore_interp_structs.h
@@ -701,6 +701,7 @@ struct _Py_interp_static_objects {
         _PyGC_Head_UNUSED _hamt_empty_gc_not_used;
         PyHamtObject hamt_empty;
         PyBaseExceptionObject last_resort_memory_error;
+        PyObject *subclasses_weakref_sentinel;
     } singletons;
 };
 
diff --git a/Include/internal/pycore_weakref.h b/Include/internal/pycore_weakref.h
index 4ed8928c0b92a8..fb2fd419f0ba78 100644
--- a/Include/internal/pycore_weakref.h
+++ b/Include/internal/pycore_weakref.h
@@ -9,6 +9,7 @@ extern "C" {
 #endif
 
 #include "pycore_critical_section.h" // Py_BEGIN_CRITICAL_SECTION()
+#include "pycore_interp_structs.h"   // PyInterpreterState
 #include "pycore_lock.h"             // PyMutex_LockFlags()
 #include "pycore_object.h"           // _Py_REF_IS_MERGED()
 #include "pycore_pyatomic_ft_wrappers.h"
@@ -127,6 +128,18 @@ extern void _PyWeakref_ClearWeakRefsNoCallbacks(PyObject *obj);
 
 PyAPI_FUNC(int) _PyWeakref_IsDead(PyObject *weakref);
 
+// Create sentinel callback object for subclasses weakrefs
+int _PyWeakref_InitSubclassSentinel(PyInterpreterState *interp);
+
+// Clear sentinel callback object
+void _PyWeakref_ClearSubclassSentinel(PyInterpreterState *interp);
+
+// Create new PyWeakReference object with sentinel callback
+PyObject * _PyWeakref_NewSubclassRef(PyObject *ob);
+
+// Check if weakref has sentinel callback
+int _PyWeakref_IsSubclassRef(PyWeakReference *weakref);
+
 #ifdef __cplusplus
 }
 #endif
diff --git a/Lib/test/test_gc.py b/Lib/test/test_gc.py
index b4cbfb6d774080..a6d9ce6f91ff2d 100644
--- a/Lib/test/test_gc.py
+++ b/Lib/test/test_gc.py
@@ -1125,6 +1125,30 @@ def test_something(self):
         """)
         assert_python_ok("-c", source)
 
+    def test_do_not_cleanup_type_subclasses_before_finalization(self):
+        # https://github.com/python/cpython/issues/135552
+        code = """
+            class BaseNode:
+                def __del__(self):
+                    BaseNode.next = BaseNode.next.next
+                    BaseNode.next.next
+
+            class Node(BaseNode):
+                pass
+
+            BaseNode.next = Node()
+            BaseNode.next.next = Node()
+        """
+        assert_python_ok("-c", textwrap.dedent(code))
+
+        code_inside_function = textwrap.dedent(F"""
+            def test():
+                {textwrap.indent(code, '    ')}
+
+            test()
+        """)
+        assert_python_ok("-c", code_inside_function)
+
 
 class IncrementalGCTests(unittest.TestCase):
     @unittest.skipIf(_testinternalcapi is None, "requires _testinternalcapi")
@@ -1518,6 +1542,7 @@ def test_ast_fini(self):
         assert_python_ok("-c", code)
 
 
+
 def setUpModule():
     global enabled, debug
     enabled = gc.isenabled()
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2025-06-23-01-07-09.gh-issue-135552.eG9vzP.rst b/Misc/NEWS.d/next/Core_and_Builtins/2025-06-23-01-07-09.gh-issue-135552.eG9vzP.rst
new file mode 100644
index 00000000000000..3d8e2e906475d1
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2025-06-23-01-07-09.gh-issue-135552.eG9vzP.rst
@@ -0,0 +1,4 @@
+Do not clear type's subclasses weak references in the GC to prevent the clearing
+of the type's subclasses list too early. This fix a crash that occurs when
+:meth:`~object.__del__` modifies the base's attributes and tries to access them
+from self.
diff --git a/Objects/typeobject.c b/Objects/typeobject.c
index 6e7471cb5941a7..55a11a74ecacc8 100644
--- a/Objects/typeobject.c
+++ b/Objects/typeobject.c
@@ -9259,7 +9259,7 @@ add_subclass(PyTypeObject *base, PyTypeObject *type)
     if (key == NULL)
         return -1;
 
-    PyObject *ref = PyWeakref_NewRef((PyObject *)type, NULL);
+    PyObject *ref = _PyWeakref_NewSubclassRef((PyObject *)type);
     if (ref == NULL) {
         Py_DECREF(key);
         return -1;
diff --git a/Objects/weakrefobject.c b/Objects/weakrefobject.c
index bd4c4ac9b3475a..e3689a63afe9b1 100644
--- a/Objects/weakrefobject.c
+++ b/Objects/weakrefobject.c
@@ -1,12 +1,17 @@
 #include "Python.h"
 #include "pycore_critical_section.h"
+#include "pycore_global_objects.h" // _Py_INTERP_STATIC_OBJECT()
+#include "pycore_interp_structs.h" // _PyInterpreterState_GET()
 #include "pycore_lock.h"
 #include "pycore_modsupport.h"    // _PyArg_NoKwnames()
 #include "pycore_object.h"        // _PyObject_GET_WEAKREFS_LISTPTR()
+#include "pycore_opcode_metadata.h" // RESUME
 #include "pycore_pyerrors.h"      // _PyErr_ChainExceptions1()
 #include "pycore_pystate.h"
 #include "pycore_weakref.h"       // _PyWeakref_GET_REF()
 
+
+
 #ifdef Py_GIL_DISABLED
 /*
  * Thread-safety for free-threaded builds
@@ -1132,3 +1137,179 @@ _PyWeakref_IsDead(PyObject *weakref)
 {
     return _PyWeakref_IS_DEAD(weakref);
 }
+
+static const uint8_t noop_func_bytecode[6] = {
+    RESUME, RESUME_AT_FUNC_START,
+    LOAD_CONST, 0,
+    RETURN_VALUE, 0
+};
+
+static const uint8_t noop_func_linetable[2] = {
+    (1 << 7)  // New entry.
+    | (PY_CODE_LOCATION_INFO_NO_COLUMNS << 3)
+    | (3 - 1),  // Three code units.
+    0,  // Offset from co_firstlineno.
+};
+
+PyCodeObject *
+create_new_noop_code(const char *filename, const char *funcname, int firstlineno)
+{
+    PyObject *nulltuple = NULL;
+    PyObject *filename_str = NULL;
+    PyObject *funcname_str = NULL;
+    PyObject *code_bytes = NULL;
+    PyObject *linetable_bytes = NULL;
+    PyObject *wr_str = NULL;
+    PyObject *consts = NULL;
+    PyObject *varnames = NULL;
+    PyCodeObject *result = NULL;
+
+    nulltuple = PyTuple_New(0);
+    if (nulltuple == NULL) {
+        goto failed;
+    }
+    funcname_str = PyUnicode_FromString(funcname);
+    if (funcname_str == NULL) {
+        goto failed;
+    }
+    filename_str = PyUnicode_FromString(filename);
+    if (filename_str == NULL) {
+        goto failed;
+    }
+    code_bytes = PyBytes_FromStringAndSize((const char *)noop_func_bytecode, 6);
+    if (code_bytes == NULL) {
+        goto failed;
+    }
+    linetable_bytes = PyBytes_FromStringAndSize((const char *)noop_func_linetable, 2);
+    if (linetable_bytes == NULL) {
+        goto failed;
+    }
+
+    consts = PyTuple_Pack(1, Py_None);
+    if (consts == NULL) {
+        goto failed;
+    }
+
+    wr_str = PyUnicode_FromString("wr");
+    if (wr_str == NULL) {
+        goto failed;
+    }
+
+    varnames = PyTuple_Pack(1, wr_str);
+    if (varnames == NULL) {
+        goto failed;
+    }
+
+#define emptybytes (PyObject *)&_Py_SINGLETON(bytes_empty)
+
+    int argcount = 1;
+    int posonlyargcount = 0;
+    int kwonlyargcount = 0;
+    int nlocals = 1;
+    int stacksize = 1;
+    int flags = CO_OPTIMIZED | CO_NEWLOCALS;
+
+    result = PyUnstable_Code_NewWithPosOnlyArgs(
+        argcount, posonlyargcount, kwonlyargcount, nlocals, stacksize, flags,
+        code_bytes, consts, nulltuple, varnames, nulltuple, nulltuple,
+        filename_str, funcname_str, funcname_str, firstlineno,
+        linetable_bytes, emptybytes);
+
+#undef emptybytes
+
+failed:
+    Py_XDECREF(nulltuple);
+    Py_XDECREF(funcname_str);
+    Py_XDECREF(filename_str);
+    Py_XDECREF(code_bytes);
+    Py_XDECREF(linetable_bytes);
+    Py_XDECREF(consts);
+    Py_XDECREF(varnames);
+    Py_XDECREF(wr_str);
+
+    return result;
+}
+
+int
+_PyWeakref_InitSubclassSentinel(PyInterpreterState *interp)
+{
+    int status = 0;
+
+    PyObject *globals = NULL;
+    PyObject *func = NULL;
+    PyObject *code = (PyObject *)create_new_noop_code(
+        "<generated>",
+        "<subclasses_weakref_sentinel>",
+        1);
+    if (code == NULL) {
+        return -1;
+    }
+
+    globals = PyDict_New();
+    if (globals == NULL) {
+        status = -1;
+        goto failed;
+    }
+
+    func = PyFunction_New(code, globals);
+    if (func == NULL) {
+        status = -1;
+        goto failed;
+    }
+
+#ifdef Py_DEBUG
+    PyObject *result = PyObject_CallOneArg(func, Py_None);
+    if (!result) {
+        status = -1;
+        goto failed;
+    }
+    Py_DECREF(result);
+#endif
+
+    _Py_SetImmortal(func);
+    _Py_INTERP_SINGLETON(interp, subclasses_weakref_sentinel) = func;
+
+failed:
+    Py_XDECREF(code);
+    Py_XDECREF(globals);
+
+    return status;
+}
+
+void
+_PyWeakref_ClearSubclassSentinel(PyInterpreterState *interp)
+{
+    if (interp == interp->runtime->interpreters.main) {
+        PyObject *func = _Py_INTERP_SINGLETON(interp, subclasses_weakref_sentinel);
+
+        assert(PyObject_GC_IsTracked(func) == 0);
+        _Py_SetMortal(_Py_INTERP_SINGLETON(interp, subclasses_weakref_sentinel), 1);
+        PyObject_GC_Track(func);
+
+        Py_CLEAR(_Py_INTERP_SINGLETON(interp, subclasses_weakref_sentinel));
+    }
+}
+
+PyObject *
+_PyWeakref_NewSubclassRef(PyObject *ob)
+{
+    PyInterpreterState *interp = _PyInterpreterState_GET();
+    if (interp != interp->runtime->interpreters.main) {
+        interp = interp->runtime->interpreters.main;
+    }
+    PyObject *func = _Py_INTERP_SINGLETON(interp, subclasses_weakref_sentinel);
+    return PyWeakref_NewRef(ob, func);
+}
+
+int
+_PyWeakref_IsSubclassRef(PyWeakReference *weakref)
+{
+    assert(weakref != NULL);
+
+    PyInterpreterState *interp = _PyInterpreterState_GET();
+    if (interp != interp->runtime->interpreters.main) {
+        interp = interp->runtime->interpreters.main;
+    }
+    PyObject *func = _Py_INTERP_SINGLETON(interp, subclasses_weakref_sentinel);
+    return func != NULL && weakref->wr_callback == func;
+}
diff --git a/Python/gc.c b/Python/gc.c
index 7b0e6d6e803504..da162d4c3fff91 100644
--- a/Python/gc.c
+++ b/Python/gc.c
@@ -906,8 +906,15 @@ handle_weakrefs(PyGC_Head *unreachable, PyGC_Head *old)
              * reference cycle.  If we don't clear the weakref, the callback
              * will run and potentially cause a crash.  See bpo-38006 for
              * one example.
+             *
+             * If this is a subclass weakref we can safely ignore it's cleanup.
              */
-            _PyWeakref_ClearRef((PyWeakReference *)op);
+            if (!_PyWeakref_IsSubclassRef((PyWeakReference *)op)) {
+                _PyWeakref_ClearRef((PyWeakReference *)op);
+            }
+            else {
+                continue;
+            }
         }
 
         if (! _PyType_SUPPORTS_WEAKREFS(Py_TYPE(op))) {
@@ -925,9 +932,20 @@ handle_weakrefs(PyGC_Head *unreachable, PyGC_Head *old)
          * all the weakrefs, and move the weakrefs with callbacks
          * that must be called into wrcb_to_call.
          */
-        for (wr = *wrlist; wr != NULL; wr = *wrlist) {
+        PyWeakReference *wr_next = *wrlist;
+        for (wr = wr_next; wr != NULL; wr = wr_next) {
             PyGC_Head *wrasgc;                  /* AS_GC(wr) */
 
+            wr_next = wr->wr_next;
+
+            /* If this is a subclass weakref we can safely ignore it's cleanup.
+             * It has only sentinel callback (no-op) and we also can safely
+             * not invoke them.
+             */
+            if (_PyWeakref_IsSubclassRef(wr) == 1) {
+                continue;
+            }
+
             /* _PyWeakref_ClearRef clears the weakref but leaves
              * the callback pointer intact.  Obscure:  it also
              * changes *wrlist.
diff --git a/Python/pylifecycle.c b/Python/pylifecycle.c
index 724fda63511282..aa80c057dcfbc0 100644
--- a/Python/pylifecycle.c
+++ b/Python/pylifecycle.c
@@ -1376,6 +1376,12 @@ init_interp_main(PyThreadState *tstate)
         return _PyStatus_ERR("failed to set builtin dict watcher");
     }
 
+    if (is_main_interp) {
+        if (_PyWeakref_InitSubclassSentinel(interp) < 0) {
+            return _PyStatus_ERR("failed to create subclasses weakref sentinel");
+        }
+    }
+
     assert(!_PyErr_Occurred(tstate));
 
     return _PyStatus_OK();
@@ -1870,6 +1876,10 @@ finalize_interp_types(PyInterpreterState *interp)
     _PyObject_FinalizeUniqueIdPool(interp);
 #endif
 
+    // We clear subclass sentinel here because some weakrefs may
+    // hold reference to it (for example, type's subclasses)
+    _PyWeakref_ClearSubclassSentinel(interp);
+
     _PyCode_Fini(interp);
 
     // Call _PyUnicode_ClearInterned() before _PyDict_Fini() since it uses
diff --git a/Python/pystate.c b/Python/pystate.c
index 0d4c26f92cec90..d95831f8ae6773 100644
--- a/Python/pystate.c
+++ b/Python/pystate.c
@@ -24,6 +24,7 @@
 #include "pycore_stackref.h"      // Py_STACKREF_DEBUG
 #include "pycore_time.h"          // _PyTime_Init()
 #include "pycore_uniqueid.h"      // _PyObject_FinalizePerThreadRefcounts()
+#include "pycore_weakref.h"       // _PyWeakref_ClearSubclassSentinel()
 
 
 /* --------------------------------------------------------------------------