diff --git a/compiler/rustc_codegen_llvm/src/llvm_util.rs b/compiler/rustc_codegen_llvm/src/llvm_util.rs
index 0fb987bdf82ed..3bcd417941e96 100644
--- a/compiler/rustc_codegen_llvm/src/llvm_util.rs
+++ b/compiler/rustc_codegen_llvm/src/llvm_util.rs
@@ -405,6 +405,8 @@ fn update_target_reliable_float_cfg(sess: &Session, cfg: &mut TargetConfig) {
         ("mips64" | "mips64r6", _) => false,
         // Selection bug <https://github.com/llvm/llvm-project/issues/95471>
         ("nvptx64", _) => false,
+        // Unsupported https://github.com/llvm/llvm-project/issues/121122
+        ("amdgpu", _) => false,
         // ABI bugs <https://github.com/rust-lang/rust/issues/125109> et al. (full
         // list at <https://github.com/rust-lang/rust/issues/116909>)
         ("powerpc" | "powerpc64", _) => false,